Description

2-Benzyloxy-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex pharmaceutical and agrochemical intermediates. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce the 2-benzyloxy-5-(trifluoromethyl)pyridin-3-yl moiety into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides by incorporating the trifluoromethylpyridine scaffold, known for enhancing biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where the boronic acid group facilitates polymerization or functionalization.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Benzyloxy-5-(Trifluoromethyl)Pyridine-3-Boronic Acid
CAS No.	850864-60-7
Molecular Formula	C13H11BF3NO3
Molecular Weight	297.04 g/mol
Synonyms	[2-(Benzyloxy)-5-(trifluoromethyl)pyridin-3-yl]boronic acid; 2-Benzyloxy-5-trifluoromethylpyridine-3-boronic acid; 3-Pyridineboronic acid, 2-(phenylmethoxy)-5-(trifluoromethyl)-; 2-(Benzyloxy)-5-(trifluoromethyl)-3-pyridineboronic acid; 850864-60-7; B-2-(Benzyloxy)-5-(trifluoromethyl)-3-pyridinylboronic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-value chemical intermediates. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all critical quality attributes are available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.