Description

3-(2,2,2-Trifluoroethoxy)Phenylboronic Acid is a specialized organoboron compound that serves as a critical building block in modern synthetic chemistry. Its value lies in the unique trifluoroethoxy substituent, which imparts distinct electronic and steric properties, making it a sought-after intermediate for constructing complex molecular architectures. This high-purity boronic acid is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the incorporation of a trifluoroethoxy-phenyl moiety for enhanced metabolic stability or bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the specific fluorine pattern is desirable for activity.
• Material Science Research: Employed in the creation of advanced organic materials, such as ligands for catalysts or monomers for specialty polymers.
• Suzuki-Miyaura Cross-Coupling: A pivotal reagent in palladium-catalyzed cross-coupling reactions to form biaryl and other carbon-carbon bonds with high efficiency and selectivity.
• Chemical Biology & Probe Development: Useful in synthesizing molecular probes and tags for studying biological systems due to the specific reactivity of the boronic acid group.

Basic Information

Product Name	3-(2,2,2-Trifluoroethoxy)Phenylboronic Acid
CAS No.	850593-08-7
Molecular Formula	C8H8BF3O3
Molecular Weight	219.96 g/mol
Synonyms	[3-(2,2,2-Trifluoroethoxy)phenyl]boronic acid; 3-(2,2,2-Trifluoroethoxy)benzeneboronic acid; (3-(2,2,2-Trifluoroethoxy)phenyl)boronic acid; Boronic acid, B-[3-(2,2,2-trifluoroethoxy)phenyl]-; 3-Trifluoroethoxyphenylboronic Acid; 3-(Trifluoroethoxy)phenylboronic Acid; 850593-08-7; B-[3-(2,2,2-Trifluoroethoxy)phenyl]boronic acid
EINECS	Contact for details

Quality Control

Our 3-(2,2,2-Trifluoroethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every lot to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.