Description

(3-Chloro-4-Fluoro-5-Nitro)Benzeneboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique substitution pattern makes it an indispensable reagent for constructing complex molecular architectures via cross-coupling reactions. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its role is pivotal in accelerating drug discovery and the development of new crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, leveraging its halogen and nitro groups for structural diversity.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and sensors.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in homogeneous catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A vital raw material for CROs and CDMOs offering bespoke chemical synthesis services to global clients.

Basic Information

Item	Detail
Product Name	(3-Chloro-4-Fluoro-5-Nitro)Benzeneboronic Acid
CAS No.	850568-73-9
Molecular Formula	C6H4BClFNO4
Molecular Weight	219.36 g/mol
Synonyms	3-Chloro-4-fluoro-5-nitrobenzeneboronic acid; (3-Chloro-4-fluoro-5-nitrophenyl)boronic acid; 3-Chloro-4-fluoro-5-nitrobenzeneboronic acid pinacol ester (precursor); 850568-73-9; Boronic acid, B-(3-chloro-4-fluoro-5-nitrophenyl)-; 5-Nitro-3-chloro-4-fluorobenzeneboronic acid
EINECS	Contact for details

Quality Control

Every batch of (3-Chloro-4-Fluoro-5-Nitro)Benzeneboronic Acid is manufactured and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.