Description

2-(n-Boc-Aminomethyl)-4-Fluorophenylboronic Acid is a high-value, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides that require the incorporation of fluorinated aromatic systems.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where fluorinated boronic acids modify electronic properties.
• Peptide Mimetics & PROTACs: The protected aminomethyl group allows for selective deprotection and further functionalization in the synthesis of peptide-like molecules and proteolysis-targeting chimeras.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and labeling strategies due to its orthogonal reactivity.
• Scale-Up Process Development: Supplied in quantities suitable for process chemistry optimization and pilot-scale manufacturing.

Basic Information

Product Name	2-(n-Boc-Aminomethyl)-4-Fluorophenylboronic Acid
CAS No.	850568-64-8
Molecular Formula	C₁₃H₁₉BFNO₄
Molecular Weight	283.10 g/mol
Synonyms	2-((tert-Butoxycarbonylamino)methyl)-4-fluorobenzeneboronic Acid; 4-Fluoro-2-((((2-methyl-2-propanyl)oxy)carbonylamino)methyl)benzeneboronic Acid; 2-(Boc-Aminomethyl)-4-fluorophenylboronic Acid; N-Boc-2-(4-Fluorophenyl)ethylamine Boronic Acid Pinacol Ester (hydrolyzed); BOC-AMFBA; tert-Butyl N-[(4-fluoro-2-boronobenzyl)]carbamate
EINECS	Contact for details

Quality Control

Every batch of 2-(n-Boc-Aminomethyl)-4-Fluorophenylboronic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive applications like pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (HPLC), identity (NMR, IR), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.