Description

(2-Boc-Aminomethyl-5-Fluorophenyl)Boronic Acid is a sophisticated bifunctional building block that combines a boronic acid moiety with a protected amine group. This compound is of significant value in modern synthetic chemistry, particularly for the construction of complex molecules via cross-coupling reactions. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl structures found in drug candidates.
• Protease Inhibitor Development: Used in the research and synthesis of molecules targeting proteolytic enzymes, leveraging the boronic acid group's affinity.
• Agrochemical Synthesis: Employed in creating novel herbicides and fungicides with fluorinated aromatic components for enhanced activity and stability.
• Material Science Research: Serves as a monomer or linker in the development of advanced organic frameworks and polymeric materials.
• Chemical Biology Probes: Utilized to create activity-based probes for studying enzyme function and protein interactions.
• Peptidomimetic Chemistry: The Boc-protected amine allows for the incorporation of this fragment into peptide-like structures with modified properties.

Basic Information

Product Name	(2-Boc-Aminomethyl-5-Fluorophenyl)Boronic Acid
CAS No.	850568-43-3
Molecular Formula	C₁₃H₁₉BFNO₄
Molecular Weight	283.11 g/mol
Synonyms	5-Fluoro-2-((tert-butoxycarbonylamino)methyl)phenylboronic acid; N-Boc-2-Amino-5-fluorobenzylboronic acid; (5-Fluoro-2-(((2-methylpropan-2-yl)oxy)carbonylamino)methyl)phenyl)boronic acid; 2-(N-Boc-Aminomethyl)-5-fluorophenylboronic acid; B-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]methyl]-5-fluorophenyl]boronic acid; tert-Butyl N-[(2-borono-4-fluorophenyl)methyl]carbamate; CAS 850568-43-3
EINECS	Contact for details

Quality Control

Our (2-Boc-Aminomethyl-5-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.