Description

4-(4-Fluorophenyl)Aminocarbonylphenylboronic Acid is a specialized boronic acid derivative featuring a fluorinated amide linker, making it a valuable building block in modern synthetic chemistry. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing biphenyl or heterobiaryl motifs for oncology, CNS, and metabolic disease targets.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides by enabling the introduction of the fluorophenyl-carbonylphenylboronic acid scaffold.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and bioconjugation reagents leveraging its boronic acid functionality.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel palladium catalyst ligands to improve coupling efficiency and selectivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis and library production for drug discovery campaigns.

Basic Information

Item	Details
Product Name	4-(4-Fluorophenyl)Aminocarbonylphenylboronic Acid
CAS No.	850568-27-3
Molecular Formula	C13H11BFNO3
Molecular Weight	259.04 g/mol
Synonyms	[4-(4-Fluorobenzamido)phenyl]boronic acid; 4-(4-Fluorobenzamido)benzeneboronic acid; 4-Carbamoyl-4'-fluorobiphenyl-3-boronic acid; 4'-Fluoro-[1,1'-biphenyl]-4-carboxamide-3-boronic acid; 4-(4-Fluorophenyl)carbamoylphenylboronic acid; B-[4-[(4-Fluorophenyl)carbamoyl]phenyl]boronic acid; 850568-27-3; Amide-linked fluorophenyl phenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 4-(4-Fluorophenyl)Aminocarbonylphenylboronic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding research and scale-up processes. Certificates of Analysis (COA) with full analytical data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.