Description

2-(Trifluoromethyl)-3-Fluoro-Phenylboronic Acid is a high-purity, multi-fluorinated boronic acid derivative essential for modern synthetic chemistry. This compound matters as a versatile and critical building block in cross-coupling reactions, enabling the precise construction of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those requiring fluorinated aromatic scaffolds for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl and fluoro substituents contribute to improved lipophilicity and biological activity.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials with unique optical or electronic properties.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes, leveraging the boronic acid group for bioconjugation.
• Catalyst Ligand Preparation: Utilized to synthesize sophisticated ligand systems for transition metal catalysts used in asymmetric synthesis and other specialized catalytic processes.

Basic Information

Product Name	2-(Trifluoromethyl)-3-Fluoro-Phenylboronic Acid
CAS No.	850411-12-0
Molecular Formula	C7H5BF4O2
Molecular Weight	207.92 g/mol
Synonyms	[3-Fluoro-2-(trifluoromethyl)phenyl]boronic acid; 2-Fluoro-α,α,α-trifluoro-m-tolueneboronic acid; 3-Fluoro-2-trifluoromethylbenzeneboronic acid; 2-(Trifluoromethyl)-3-fluorobenzeneboronic acid; Boronic acid, B-[3-fluoro-2-(trifluoromethyl)phenyl]-; 850411-12-0; (3-Fluoro-2-(trifluoromethyl)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethyl)-3-Fluoro-Phenylboronic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by NMR, HPLC, and other relevant methods is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.