Description

n-(2H-3,4,5,6-Tetrahydropyran-2-Yloxy)-3-[(Fluoren-9-Ylmethoxy)Carbonylamino]Propanamide is a sophisticated, high-purity chemical intermediate designed for advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring precise molecular building blocks for complex organic synthesis, particularly in pharmaceutical development. It is primarily utilized by fine chemical producers and R&D laboratories in the life sciences sector for constructing novel active pharmaceutical ingredients (APIs) and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates and novel active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis, where the Fmoc and THP protecting groups are strategically employed.
• Protecting Group Strategy: Serves as a reagent featuring both acid-labile tetrahydropyranyl (THP) and base-labile fluorenylmethyloxycarbonyl (Fmoc) protecting groups for orthogonal deprotection sequences.
• Bioconjugation: Employed in the development of linker molecules and probes for bioconjugation and labeling applications in medicinal chemistry.
• Custom Synthesis: An essential starting material for contract research and manufacturing organizations (CROs/CMOs) specializing in custom organic synthesis.
• Academic Research: Utilized in university and institutional laboratories for methodological development in synthetic organic chemistry and chemical biology.

Basic Information

Product Name	n-(2H-3,4,5,6-Tetrahydropyran-2-Yloxy)-3-[(Fluoren-9-Ylmethoxy)Carbonylamino]Propanamide
CAS No.	850349-60-9
Molecular Formula	C28H28N2O5
Molecular Weight	472.53 g/mol
Synonyms	3-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-N-(tetrahydro-2H-pyran-2-yloxy)propanamide; Fmoc-β-Ala-OTHP; N-(THP-O)-3-(Fmoc-amino)propanamide; 3-[(Fmoc)amino]-N-(tetrahydropyran-2-yloxy)propanamide; Fmoc-β-alanine tetrahydropyranyl ester; Propanamide, N-(2H-3,4,5,6-tetrahydropyran-2-yloxy)-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-; Fmoc-β-Ala-OTHP ester; β-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 2-(tetrahydro-2H-pyran-2-yl) ester
EINECS	Contact for details

Quality Control

Every batch of n-(2H-3,4,5,6-Tetrahydropyran-2-Yloxy)-3-[(Fluoren-9-Ylmethoxy)Carbonylamino]Propanamide is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications suitable for research and pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.