Description

(R)-(+)-5,5'-Bis[Di(3,5-Xylyl)Phosphino]-4,4'-Bi-1,3-Benzodioxole,Min.98%(R)-Dm-Segphos CAS NO 850253-53-1 is a high-purity, chiral bisphosphine ligand belonging to the Segphos family, renowned for its exceptional enantioselectivity in asymmetric catalysis. This compound is critical for enabling efficient and selective synthetic routes to complex chiral molecules, which are foundational to modern pharmaceutical and fine chemical manufacturing. It is an essential tool for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-performance catalysts for hydrogenation, cross-coupling, and other transition metal-catalyzed reactions.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for producing single-enantiomer pharmaceutical intermediates and active ingredients.
• Pharmaceutical Synthesis: Used in the development and commercial-scale production of chiral drugs, including APIs for cardiovascular, central nervous system, and antiviral therapies.
• Agrochemical Manufacturing: Enables the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Cross-Coupling Reactions: Facilitates asymmetric versions of Suzuki-Miyaura, Heck, and other C-C bond-forming reactions to construct complex molecular architectures.
• Fine Chemical & Flavor/Fragrance Production: Applied in the synthesis of high-value chiral compounds for flavors, fragrances, and advanced materials.
• Catalyst Screening & Process Development: A key component in catalyst libraries for high-throughput screening and optimization of new asymmetric transformations in R&D laboratories.
• Academic & Industrial Research: Serves as a benchmark ligand in methodological studies for developing new catalytic cycles and understanding stereocontrol mechanisms.

Basic Information

Product Name	(R)-(+)-5,5'-Bis[Di(3,5-Xylyl)Phosphino]-4,4'-Bi-1,3-Benzodioxole (Min. 98%)
CAS No.	850253-53-1
Molecular Formula	C58H52O4P2
Molecular Weight	874.97 g/mol
Synonyms	(R)-DM-Segphos; (R)-5,5'-Bis[di(3,5-dimethylphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (R)-2,2'-Dimethyl-4,4',6,6'-tetrakis(3,5-dimethylphenyl)-2,2'-bisdibenzo[d,f][1,3,2]dioxaphosphepin; (R)-DM-SEGPHOS; (R)-DMB-SEGPHOS; (R)-3,3',5,5'-Tetramethyl-2,2'-bis(di(3,5-xylyl)phosphino)-1,1'-biphenyl; (R)-Bisphosphine Ligand DM-Segphos
EINECS	Contact for details

Quality Control

Our (R)-DM-Segphos is manufactured under strict quality-controlled conditions to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including chiral HPLC for enantiopurity verification and 31P/1H NMR for structural confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. Our quality system supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 98.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Water Content (KF)	Max. 0.5%
Residue on Ignition	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.