Description

(S)-1-{(S)-2-[2-(Dicyclohexylphosphino)Phenyl]Ferrocenyl}Ethylbis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, prized for its exceptional stereoselectivity in asymmetric catalysis. Its value lies in enabling the synthesis of complex, enantiomerically pure pharmaceutical intermediates and fine chemicals with high efficiency and yield. This advanced ligand is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise control over molecular chirality.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Manufacturing: Used in the asymmetric synthesis of chiral herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Cross-Coupling Reactions: Facilitates challenging asymmetric C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, with high enantiomeric excess.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and process chemistry within university and corporate research laboratories.
• Fine Chemical Production: Enables the commercial-scale manufacture of enantiopure flavors, fragrances, and advanced materials.

Basic Information

Product Name	(S)-1-{(S)-2-[2-(Dicyclohexylphosphino)Phenyl]Ferrocenyl}Ethylbis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphine
CAS No.	849925-22-0
Molecular Formula	C51H48F12FeP2
Molecular Weight	982.66 g/mol
Synonyms	(S,S)-Bis(3,5-bis(trifluoromethyl)phenyl)(1-((S)-2-(dicyclohexylphosphino)phenyl)ferrocen-1-yl)ethylphosphine; Josiphos SL-J009-1; SL-J009-1; (S)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi(3,5-bis(trifluoromethyl)phenyl)phosphine; (S,S)-Bis(3,5-bis(trifluoromethyl)phenyl)(1-((S)-2-(dicyclohexylphosphino)phenyl)ferrocen-1-yl)ethylphosphine; Chiral Josiphos-type ligand; Ferrocenyl diphosphine ligand J009.
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management protocols to ensure exceptional purity and chiral integrity, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity (by HPLC/NMR), and metal residue profiles. Our production adheres to cGMP guidelines where applicable, supporting our commitment to supply reliability for critical pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Moisture Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.