Description

(S)-1-{(S)-2-[2-(Diphenylphosphino)Phenyl]-Ferrocenyl}Ethylbis[3,5-Bis-(Trifluoromethyl)Phenyl]Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to impart exceptional enantioselectivity and activity in transition metal-catalyzed reactions, which is critical for producing high-purity, single-enantiomer intermediates. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance ligands for complex synthetic transformations.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for synthesizing chiral pharmaceutical building blocks.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions (e.g., Suzuki-Miyaura, Heck) and allylic substitution to construct complex molecular architectures with high stereocontrol.
• Pharmaceutical Intermediate Synthesis: Key catalyst component for the production of active pharmaceutical ingredients (APIs) requiring specific chirality, such as β-blockers, antivirals, and antidepressants.
• Agrochemical Product Development: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and for scaling up novel catalytic processes from lab to pilot plant.
• Fine Chemical Manufacturing: Facilitates the production of high-value chiral flavors, fragrances, and specialty materials.

Basic Information

Product Name	(S)-1-{(S)-2-[2-(Diphenylphosphino)Phenyl]-Ferrocenyl}Ethylbis[3,5-Bis-(Trifluoromethyl)Phenyl]Phosphine
CAS No.	849925-17-3
Molecular Formula	C51H37F12FeP2
Molecular Weight	962.61 g/mol
Synonyms	(S,S)-BisP* Ferrocene Ligand; (S,S)-BisP*; Josiphos SL-J009-1; (S)-1-[(R)-2-[2-(Diphenylphosphino)phenyl]ferrocenyl]ethyldi(3,5-bis(trifluoromethyl)phenyl)phosphine; (S)-1-((S)-2-(2-(Diphenylphosphino)phenyl)ferrocenyl)ethyldi(3,5-bis(trifluoromethyl)phenyl)phosphine; SL-J009-1; (S,S)-BisP*-type Ferrocenyl Diphosphine; Chiral Josiphos Derivative
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management protocols to ensure consistent high purity and performance. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and identity confirmation. Our production adheres to cGMP principles where applicable, and we support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.