Description

(R)-1-Diphenylphosphino-2-[(S)- -(Dimethylamino)-2-(Diphenylphosphino)Benz is a sophisticated, chiral diphosphine ligand designed for asymmetric catalysis. This compound is valued for its ability to impart high enantioselectivity and catalytic efficiency in critical synthetic transformations. It is an essential tool for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries developing novel active ingredients and advanced materials.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Employed in palladium-catalyzed C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, to construct complex molecular architectures.
• Hydroformylation: Used in the asymmetric hydroformylation of alkenes to produce chiral aldehydes, which are valuable building blocks.
• Pharmaceutical Intermediate Synthesis: Critical for the production of enantiomerically pure active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Agrochemical Manufacturing: Applied in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: Serves as a fundamental research chemical for developing new catalytic methodologies and exploring novel reaction pathways.

Basic Information

Product Name	(R)-1-Diphenylphosphino-2-[(S)- -(Dimethylamino)-2-(Diphenylphosphino)Benz
CAS No.	849925-15-1
Molecular Formula	C33H31NP2
Molecular Weight	503.55 g/mol
Synonyms	(R)-1-Diphenylphosphino-2-[(S)-2-(Dimethylamino)-2-(diphenylphosphino)benzyl]benzene; (R)-1-Diphenylphosphino-2-[(S)-2-(N,N-Dimethylamino)-2-(diphenylphosphino)benzyl]benzene; (R)-1-Diphenylphosphino-2-[(S)-α-(Dimethylamino)-2-(diphenylphosphino)benzyl]benzene; Josiphos-type ligand derivative; Chiral diphosphine ligand; Asymmetric hydrogenation ligand; P,N-Ligand
EINECS	Contact for details

Quality Control

Our production of (R)-1-Diphenylphosphino-2-[(S)- -(Dimethylamino)-2-(Diphenylphosphino)Benz adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for catalytic applications. All materials are characterized by advanced analytical techniques, including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.