Description

(As,As)-1,1'-Bis[-(Dimethylamino)Benzyl]-(R,R)-2,2'-Bis{Bis[3,5-Bis(Trifluoromethyl)phenyl]phosphino}ethane is a highly specialized, chiral bisphosphine ligand of significant value in asymmetric catalysis. Its precise stereochemistry and electron-deficient arylphosphine groups make it an exceptional catalyst component for creating chiral environments in transition metal complexes. This compound is primarily needed by pharmaceutical and fine chemical R&D teams developing novel synthetic routes for active pharmaceutical ingredients (APIs) and high-value chiral intermediates.

Application

• Asymmetric Hydrogenation: A key ligand for rhodium or ruthenium catalysts in the enantioselective reduction of prochiral olefins, enamines, and ketones.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer drug candidates with high optical purity for therapeutic applications.
• Asymmetric C-C Bond Formation: Used in cross-coupling and allylic substitution reactions to construct complex chiral carbon frameworks.
• Catalyst Screening Libraries: A valuable component in high-throughput screening for discovering new asymmetric transformations.
• Academic & Industrial Research: Serves as a critical tool for methodology development in organic synthesis and catalysis science.
• Agrochemical Synthesis: Potential application in creating chiral active ingredients for crop protection products.

Basic Information

Item	Details
Product Name	(As,As)-1,1'-Bis[-(Dimethylamino)Benzyl]-(R,R)-2,2'-Bis{Bis[3,5-Bis(Trifluoromethyl)phenyl]phosphino}ethane
CAS No.	849925-10-6
Molecular Formula	C66H56F24N2P4
Molecular Weight	1445.94 g/mol
Synonyms	(R,R)-DuanPhos; (R,R)-DuanPhos ligand; (R,R)-1,1'-Bis[α-(Dimethylamino)benzyl]-2,2'-bis[bis(3,5-bis(trifluoromethyl)phenyl)phosphino]ethane; (R,R)-DuanPhos (with (As,As) configuration); DuanPhos (R,R) isomer; (R,R)-Bisphosphine ligand DuanPhos; (R,R)-DuanPhos (C2-symmetric); Asymmetric bisphosphine ligand CAS 849925-10-6
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced and tested under strict quality management to ensure identity, purity, and enantiomeric excess. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chiral purity (by HPLC), elemental analysis, and spectroscopic data. Our commitment to reproducible high performance in catalytic applications is paramount. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or ambient light should be avoided to maintain catalytic activity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.