Description

(S)-1-[(R)-2-(Di-Tert.-Butylphosphino)Ferrocenyl]Ethylbis(2-Methylphenyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity and catalytic activity in critical carbon-carbon and carbon-heteroatom bond-forming reactions. This ligand is essential for researchers and process chemists in the pharmaceutical and fine chemical industries developing novel active pharmaceutical ingredients (APIs) and advanced organic intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, crucial for producing single-enantiomer pharmaceutical building blocks.
• Cross-Coupling Reactions: Employed in asymmetric Suzuki-Miyaura, Heck, and other palladium-catalyzed cross-couplings to construct complex, chiral biaryl and olefinic structures.
• Pharmaceutical Intermediate Synthesis: Key catalyst component in the scalable production of chiral drugs for therapeutic areas such as oncology, cardiology, and central nervous system disorders.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Process R&D: A vital tool for methodology development and optimizing enantioselective synthetic routes in research laboratories.
• Fine Chemical Manufacturing: Facilitates the production of high-value chiral flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	(S)-1-[(R)-2-(Di-Tert.-Butylphosphino)Ferrocenyl]Ethylbis(2-Methylphenyl)Phosphine
CAS No.	849924-77-2
Molecular Formula	C35H44FeP2
Molecular Weight	582.50 g/mol
Synonyms	(S,R)-Josiphos SL-J009-1; (S)-1-[(R)-2-(Bis(1,1-dimethylethyl)phosphino)ferrocenyl]ethyldi(2-methylphenyl)phosphine; Josiphos ligand SL-J009-1; (S)-1-[(R)-2-(Di-tert-butylphosphino)ferrocenyl]ethyldi-o-tolylphosphine; (S)-1-[(R)-2-(Di-tert-butylphosphino)ferrocenyl]ethyl-di-o-tolylphosphine; (S,R)-JOSIPHOS; Chiral Ferrocenyl Phosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under stringent quality management systems to ensure exceptional purity and consistent enantiomeric excess (ee). We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as assay (by 31P NMR or HPLC), chiral purity, and residual metal content. Our production adheres to cGMP principles where required, supporting our clients' regulatory filings for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (31P NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Trace Metals (ICP-MS)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.