Description

(R)-1-[(S)-2-(Di-Tert.-Butylphosphino)Ferrocenyl]Ethylbis(2-Methylphenyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity and catalytic activity in critical carbon-carbon and carbon-heteroatom bond-forming reactions. This ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who are developing novel, single-enantiomer active ingredients and advanced intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing chiral alcohols and amines in pharmaceutical synthesis.
• Cross-Coupling Reactions: Employed in asymmetric Suzuki-Miyaura, Negishi, and Buchwald-Hartwig amination reactions to construct stereogenic centers with high fidelity.
• Pharmaceutical Intermediate Synthesis: Key catalyst component for manufacturing enantiopure drug candidates targeting CNS disorders, cardiovascular diseases, and oncology.
• Agrochemical Production: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Fine Chemical and Flavor/Fragrance Synthesis: Enables the production of high-value, enantiomerically pure aroma chemicals and specialty intermediates.
• Academic and Process R&D: A vital tool for methodology development and scaling up asymmetric catalytic processes from lab to pilot plant.

Basic Information

Product Name	(R)-1-[(S)-2-(Di-Tert.-Butylphosphino)Ferrocenyl]Ethylbis(2-Methylphenyl)Phosphine
CAS No.	849924-76-1
Molecular Formula	C35H44FeP2
Molecular Weight	582.50 g/mol
Synonyms	(R)-(S)-Josiphos SL-J009-1; (R)-1-[(S)-2-(Bis(1,1-dimethylethyl)phosphino)ferrocenyl]ethyldi(2-methylphenyl)phosphine; Josiphos SL-J009-1; (R)-1-[(S)-2-(Di-tert-butylphosphino)ferrocenyl]ethyldi-o-tolylphosphine; (R)-1-[(S)-2-(Di-tert-butylphosphino)ferrocenyl]ethyl-di-o-tolylphosphine; (R)-1-[(S)-2-(Di-tert-butylphosphino)ferrocenyl]ethylbis(2-methylphenyl)phosphine; (R)-1-[(S)-2-(Di-tert-butylphosphino)ferrocenyl]ethylbis(o-tolyl)phosphine; Chiral Josiphos-type ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is synthesized and purified under stringent, inert conditions to ensure optimal performance and stability. Certificates of Analysis (COA) are provided, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by NMR and HPLC), and metal residue content. Our quality systems support cGMP and ISO standards for traceability, making our products suitable for demanding regulatory filings in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and decomposition. For long-term storage, keep the sealed container in a freezer at -20°C. Allow the container to reach room temperature in a dry environment before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Solubility	Soluble in common organic solvents (Toluene, THF, DCM)
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.