Description

(S)-1-{(R)-2-[Di(2-Furyl)Phosphino]Ferrocenyl}Ethylbis(2-Methylphenyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity and catalytic efficiency in critical carbon-carbon and carbon-heteroatom bond-forming reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who are developing novel synthetic routes for chiral active pharmaceutical ingredients (APIs) and other high-value intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing single-enantiomer pharmaceutical building blocks.
• Cross-Coupling Reactions: Employed in asymmetric Suzuki-Miyaura, Heck, and other palladium-catalyzed cross-couplings to construct chiral biaryl and other complex molecular architectures.
• Asymmetric Allylic Substitution: Facilitates the creation of chiral centers via nucleophilic attack on allylic substrates, a key step in natural product synthesis.
• Pharmaceutical Intermediate Synthesis: Used in the research and development (R&D) and pilot-scale production of chiral drugs targeting central nervous system (CNS), cardiovascular, and oncological diseases.
• Agrochemical Synthesis: Applied in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators for enhanced efficacy and environmental safety.
• Academic & Industrial R&D: A vital tool for methodology development in academic laboratories and for process optimization in industrial R&D departments.

Basic Information

Product Name	(S)-1-{(R)-2-[Di(2-Furyl)Phosphino]Ferrocenyl}Ethylbis(2-Methylphenyl)Phosphine
CAS No.	849924-74-9
Molecular Formula	C35H31FeO2P2
Molecular Weight	592.40 g/mol
Synonyms	(S)-1-[(R)-2-(Di-2-furanylphosphino)ferrocenyl]ethyldi(2-methylphenyl)phosphine; Josiphos SL-J009-1; (S)-1-[(R)-2-(Bis(2-furyl)phosphino)ferrocenyl]ethyldi-o-tolylphosphine; (S)-1-[(R)-2-(Di-2-furylphosphino)ferrocenyl]ethylbis(2-methylphenyl)phosphine; (S,R)-Josiphos SL-J009-1; Chiral Ferrocenyl Phosphine Ligand J009-1; SL-J009-1; (S)-1-((R)-2-(Bis(furan-2-yl)phosphino)ferrocenyl)ethylbis(2-methylphenyl)phosphine
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict inert atmosphere conditions to prevent oxidation and ensure maximum activity. We guarantee high chemical and chiral purity, verified by advanced analytical techniques including HPLC, NMR, and chiral HPLC analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and is strictly light-sensitive (protect from all light exposure). Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.