Description

(R)-1-{(S)-2-[Di(2-Furyl)Phosphino]Ferrocenyl}Ethylbis(2-Methylphenyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a critical component in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity and catalytic activity in transition metal-catalyzed reactions, enabling the production of single-enantiomer compounds. This ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing advanced intermediates and active ingredients. The compound is identified by CAS No. 849924-73-8.

Application

This chiral ligand is designed for high-performance asymmetric synthesis, primarily serving as a catalyst precursor in conjunction with transition metals.

• Asymmetric Hydrogenation: A premier application for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Asymmetric C-C Bond Formation: Critical for reactions like cross-coupling, allylic alkylation, and hydroformylation to construct complex chiral molecules.
• Pharmaceutical Intermediate Synthesis: Enables the efficient, scalable production of single-enantiomer drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in creating chiral herbicides, fungicides, and pesticides where biological activity is stereospecific.
• Fine Chemical and Fragrance Production: Applied in the synthesis of enantiomerically pure flavors, fragrances, and specialty materials.
• Academic and Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in asymmetric synthesis.

Basic Information

Product Name	(R)-1-{(S)-2-[Di(2-Furyl)Phosphino]Ferrocenyl}Ethylbis(2-Methylphenyl)Phosphine
CAS No.	849924-73-8
Molecular Formula	C35H31FeO2P2
Molecular Weight	592.40 g/mol
Synonyms	(R)-1-[(S)-2-(Di-2-furanylphosphino)ferrocenyl]ethylbis(2-methylphenyl)phosphine; Josiphos SL-J009-1; (R)-(S)-JOSIPHOS SL-J009-1; (R)-1-[(S)-2-(Bis(2-furanyl)phosphino)ferrocenyl]ethylbis(2-methylphenyl)phosphine; (R)-1-[(S)-2-(Di-2-furylphosphino)ferrocenyl]ethylbis(o-tolyl)phosphine; (R)-1-[(S)-2-(Diferrocenylphosphino)ferrocenyl]ethylbis(2-methylphenyl)phosphine (common misnomer); Chiral Ferrocenyl Josiphos Ligand; SL-J009-1 Ligand
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and performance reliability. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and chiral analysis to confirm chemical identity, high purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this product should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is between 2°C and 8°C. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Solubility	Soluble in common organic solvents (Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.