Description

(S)-1-{(R)-2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Ferrocenyl}-Ethylbis(2-methylphenyl)phosphine is a highly specialized, chiral ferrocenylphosphine ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, crucial for producing single-isomer intermediates in pharmaceutical and fine chemical synthesis. This product is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control. The compound, with CAS number 849924-52-3, represents a pinnacle of ligand design for challenging asymmetric hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation Catalysis: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones to produce chiral pharmaceutical intermediates.
• Pharmaceutical Intermediate Synthesis: Critical for constructing stereogenic centers in active pharmaceutical ingredients (APIs) for oncology, CNS, and cardiovascular drugs.
• Asymmetric Cross-Coupling Reactions: Used in C-C and C-X bond-forming reactions to create chiral biaryl and other complex molecular architectures.
• Agrochemical Synthesis: Enables the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical and Flavor/Fragrance Manufacturing: Applied in the synthesis of high-value chiral compounds where optical purity is paramount.
• Academic and Industrial R&D: A valuable tool for methodology development and exploring new asymmetric catalytic processes.
• Ligand Screening Libraries: Serves as a high-performance component in catalyst libraries for reaction optimization.

Basic Information

Product Name	(S)-1-{(R)-2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Ferrocenyl}-Ethylbis(2-methylphenyl)phosphine
CAS No.	849924-52-3
Molecular Formula	C53H56FeO2P2
Molecular Weight	842.78 g/mol
Synonyms	(S,R)-JOSIPHOS SL-J009-1; (S)-1-[(R)-2-(Bis(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl]ethyldi(2-methylphenyl)phosphine; Josiphos SL-J009-1; J009-1; SL-J009-1; Ferrocenylphosphine ligand J009-1; Chiral Josiphos-type ligand; Walphos ligand analogue
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques including Chiral HPLC, 31P NMR, and 1H NMR to confirm enantiomeric purity, chemical identity, and the absence of pro-catalyst poisons. A comprehensive Certificate of Analysis (COA) detailing purity, chiral assay, and residual solvent content is provided with every shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated place, separate from incompatible materials. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (1H NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.