Description

(S)-1-{(R)-2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Ferrocenyl}-Ethyldi(3,5-dimethylphenyl)phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, prized for its role in enabling precise stereochemical control in catalytic transformations. Its value lies in providing exceptional enantioselectivity and catalytic activity, which are critical for producing high-purity, single-enantiomer intermediates. This ligand is essential for research and process chemists in the pharmaceutical and fine chemical industries who are developing advanced synthetic routes for active pharmaceutical ingredients (APIs) and other high-value chiral molecules.

Application

• Asymmetric Hydrogenation Catalysis: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, a key step in pharmaceutical synthesis.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral building blocks and advanced intermediates used in the manufacture of novel therapeutics.
• Fine Chemical Production: Enables the synthesis of enantiomerically pure flavors, fragrances, and agrochemicals with high efficiency.
• Cross-Coupling Reactions: Can be utilized as a supporting ligand in palladium-catalyzed cross-coupling reactions to form C-C and C-X bonds.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new asymmetric catalytic processes in both academic and industrial research laboratories.
• Process Chemistry Optimization: Used to develop scalable, cost-effective, and selective manufacturing processes for chiral compounds.

Basic Information

Item	Detail
Product Name	(S)-1-{(R)-2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Ferrocenyl}-Ethyldi(3,5-dimethylphenyl)phosphine
CAS No.	849924-48-7
Molecular Formula	C53H58FeO2P2
Molecular Weight	828.80 g/mol
Synonyms	(S,R)-Josiphos SL-J009-1; (S)-1-[(R)-2-(Bis(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; Josiphos ligand SL-J009-1; SL-J009-1; (S)-1-((R)-2-(Bis(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl)ethyldi(3,5-xylyl)phosphine; Ferrocenyl phosphine ligand J009-1; Chiral Josiphos derivative
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management to ensure identity, purity, and enantiomeric excess meet the exacting standards required for catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as assay (by HPLC/NMR), chiral purity, and residual solvent content. Our quality systems support development from research to commercial scale, ensuring consistent performance and reliability for your critical asymmetric synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and is sensitive to air and moisture. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.