Description

(R)-1-{(S)-2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Ferrocenyl}-Ethyldi(3,5-dimethylphenyl)phosphine is a highly specialized, chiral ferrocenyl phosphine ligand crucial for enabling precise stereochemical control in asymmetric synthesis. Its value lies in its ability to act as a superior catalyst precursor or ligand, significantly enhancing enantioselectivity and yield in critical bond-forming reactions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-performance, single-enantiomer products.

Application

• As a key chiral ligand in asymmetric hydrogenation reactions for the production of enantiomerically pure pharmaceutical intermediates.
• Catalyst component in asymmetric cross-coupling reactions (e.g., Suzuki-Miyaura, Heck) to construct chiral biaryl systems.
• Employed in the synthesis of chiral agrochemicals and flavors & fragrances where specific stereochemistry is required for biological activity or sensory profile.
• Critical tool in academic and industrial R&D for developing new catalytic methodologies and exploring novel reaction pathways.
• Used in the preparation of advanced materials with chiral properties for electronic or optical applications.

Basic Information

Product Name	(R)-1-{(S)-2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Ferrocenyl}-Ethyldi(3,5-dimethylphenyl)phosphine
CAS No.	849924-45-4
Molecular Formula	C53H58FeO2P2
Molecular Weight	852.80 g/mol
Synonyms	(R)-(S)-Josiphos SL-J009-1; (R)-1-[(S)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl]ethyldi(3,5-xylyl)phosphine; Josiphos ligand SL-J009-1; (R)-1-[(S)-2-(Di(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; Chiral Ferrocenylphosphine Ligand J009-1; SL-J009-1; (R)-1-[(S)-2-(Bis(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management protocols to ensure exceptional purity and stereochemical integrity, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity (by HPLC/NMR), and identity confirmation. Our production adheres to cGMP principles where applicable, supporting development from laboratory to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.