Description

Josiphos SL-J216-2 is a highly specialized, chiral phosphine ligand widely recognized for its exceptional performance in asymmetric catalysis. This compound is crucial for enabling high enantioselectivity and yield in critical synthetic transformations, directly impacting the efficiency and cost-effectiveness of advanced chemical manufacturing. It is an indispensable tool for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop and produce single-enantiomer active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Pharmaceutical Manufacturing: Key catalyst component for producing chiral active pharmaceutical ingredients (APIs) with high optical purity, such as β-amino acids and unnatural amino acid derivatives.
• Agrochemical Synthesis: Used in the catalytic creation of chiral herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables asymmetric C-C and C-X bond-forming reactions for high-value fragrance, flavor, and specialty material precursors.
• Academic & Industrial R&D: A benchmark ligand in method development and discovery chemistry for novel catalytic processes.
• Catalyst Library Development: Serves as a critical component in screening libraries for identifying optimal catalytic conditions for challenging transformations.

Basic Information

Product Name	Josiphos SL-J216-2
CAS No.	849924-44-3
Molecular Formula	C33H32FeP2
Molecular Weight	546.36 g/mol
Synonyms	(R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine; (R)-(S)-JOSIPHOS SL-J216-2; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethylbis(cyclohexyl)phosphine; Josiphos Ligand J216-2; Fe-Phos J216-2; SL-J216-2; Ferrocenylphosphine ligand J216-2; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldi(cyclohexyl)phosphine
EINECS	Contact for details

Quality Control

Every batch of Josiphos SL-J216-2 is manufactured and tested under strict quality management systems to ensure consistent, high-performance material suitable for sensitive catalytic applications. Our standard grade meets rigorous internal specifications for purity and chiral integrity, with comprehensive testing including HPLC assay, chiral purity analysis, and 31P NMR verification. Certificates of Analysis (COA) detailing all relevant parameters are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
31P NMR	Conforms to reference spectrum
Solubility	Soluble in common organic solvents (THF, Toluene, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.