Description

(R)-1-{(S)-2-[Di(1-Naphthyl)Phosphino]Ferrocenyl}Ethyldi-Tert.-Butylphosphine is a highly specialized, chiral ferrocenylphosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce exceptional enantioselectivity and high catalytic activity in transition metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This ligand is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing advanced intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing chiral pharmaceutical building blocks.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions (e.g., Suzuki-Miyaura, Heck) and allylic substitution to construct complex chiral molecular architectures.
• Process Chemistry & Scale-up: Used in the development and optimization of commercial-scale synthetic routes for chiral active pharmaceutical ingredients (APIs).
• Catalyst Screening & Discovery: A valuable tool in high-throughput screening libraries for identifying new catalytic systems for challenging transformations.
• Agrochemical Synthesis: Facilitates the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial Research: Serves as a benchmark ligand in methodological studies for developing new asymmetric catalytic protocols.

Basic Information

Product Name	(R)-1-{(S)-2-[Di(1-Naphthyl)Phosphino]Ferrocenyl}Ethyldi-Tert.-Butylphosphine
CAS No.	849924-43-2
Molecular Formula	C46H48FeP2
Molecular Weight	718.65 g/mol
Synonyms	(R)-(S)-Josiphos SL-J009-1; (R)-1-[(S)-2-(Bis(1-naphthyl)phosphino)ferrocenyl]ethyldi-tert-butylphosphine; Josiphos ligand SL-J009-1; (R)-1-[(S)-2-(Di-1-naphthylphosphino)ferrocenyl]ethyl-di-tert-butylphosphine; (R)-1-[(S)-2-[Bis(1-naphthalenyl)phosphino]ferrocenyl]ethylbis(1,1-dimethylethyl)phosphine; SL-J009-1; Ferrocenylphosphine ligand J009; Chiral Josiphos derivative
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and controlled under strict inert atmosphere conditions to prevent oxidation and ensure maximum catalytic performance. We employ advanced analytical techniques including NMR (¹H, ³¹P), HPLC, and chiral analysis to verify chemical identity, enantiomeric purity, and overall quality. A comprehensive Certificate of Analysis (COA) detailing assay, chiral purity, and impurity profile is provided with each shipment to guarantee consistency and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized; containers should be flushed with inert gas after each opening to maintain purity and catalytic activity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
³¹P NMR Purity	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.