Description

(S)-1-{(R)-2-[Di(2-Furyl)Phosphino]Ferrocenyl}Ethyldi-Tert.-Butylphosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a critical component in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in transition-metal-catalyzed reactions, enabling the production of single-enantiomer intermediates essential for advanced pharmaceuticals and agrochemicals. This product is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for developing efficient and selective synthetic routes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for synthesizing chiral amino acids, alcohols, and pharmaceutical intermediates.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions (e.g., Suzuki-Miyaura, Heck) and allylic substitutions to construct complex, enantiomerically pure molecular architectures.
• Pharmaceutical Intermediate Synthesis: Key catalyst component for producing high-value, single-enantiomer active pharmaceutical ingredients (APIs) and their precursors.
• Agrochemical Product Development: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry is required for bioactivity.
• Academic & Industrial R&D: A valuable tool for methodology development in academic laboratories and for scaling up novel catalytic processes in industrial settings.
• Material Science Catalysis: Potential application in the synthesis of chiral polymers or advanced materials with specific optical properties.

Basic Information

Item	Details
Product Name	(S)-1-{(R)-2-[Di(2-Furyl)Phosphino]Ferrocenyl}Ethyldi-Tert.-Butylphosphine
CAS No.	849924-42-1
Molecular Formula	C30H35FeO2P2
Molecular Weight	536.38 g/mol
Synonyms	(S,R)-JOSIPHOS SL-J009-1; (S)-1-[(R)-2-(Bis(2-furyl)phosphino)ferrocenyl]ethyldi-tert-butylphosphine; Josiphos SL-J009-1; (S)-1-[(R)-2-(Di-2-furylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; Chiral Ferrocenyl Diphosphine Ligand; J009-1 Ligand; (S,R)-JOSIPHOS-Type Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality protocols to ensure exceptional purity and performance consistency for catalytic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity, chemical purity, and metal content. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive; prolonged exposure to air or ambient light should be avoided to maintain catalytic activity. The container should be kept in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.