Description

(R)-1-{(S)-2-[Di(2-Furyl)Phosphino]Ferrocenyl}Ethyldi-Tert.-Butylphosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to impart exceptional enantioselectivity and catalytic activity in transition metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This ligand is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who are developing new active ingredients and high-value intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for producing chiral alcohols and amines in pharmaceutical synthesis.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions (e.g., Suzuki-Miyaura, Heck) and allylic substitution to construct complex chiral molecular architectures with high fidelity.
• Pharmaceutical Intermediate Synthesis: Key catalyst component for manufacturing enantiopure active pharmaceutical ingredients (APIs), including β-blockers, antifungal agents, and antiviral drugs.
• Agrochemical Production: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Fine Chemical and Fragrance Synthesis: Facilitates the production of high-value chiral flavors, fragrances, and specialty materials.
• Academic and Process R&D: A vital tool for methodology development and scaling up new catalytic processes in research laboratories.

Basic Information

Product Name	(R)-1-{(S)-2-[Di(2-Furyl)Phosphino]Ferrocenyl}Ethyldi-Tert.-Butylphosphine
CAS No.	849924-41-0
Molecular Formula	C30H35FeO2P2
Molecular Weight	536.38 g/mol
Synonyms	(R)-(S)-JOSIPHOS SL-J009-1; Josiphos SL-J009-1; (R)-1-[(S)-2-(Bis(2-furyl)phosphino)ferrocenyl]ethyldi-tert-butylphosphine; (R)-1-[(S)-2-(Di-2-furylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; Di-tert-butyl((R)-1-((S)-2-(bis(furan-2-yl)phosphanyl)ferrocenyl)ethyl)phosphane; SL-J009-1 Ligand; JOSIPHOS-Type Ligand; Chiral Ferrocenyl Diphosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and controlled under strict quality management to ensure the high purity and consistency required for sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by NMR/HPLC), and metal content. Our production adheres to cGMP guidelines where applicable, supporting our commitment to supply reliability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). This compound is easily oxidized and strictly light-sensitive; prolonged exposure to air or light will degrade performance. The storage area should be dry, cool, and well-ventilated. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Solubility	Soluble in common organic solvents (THF, Toluene, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.