Description

(S)-1-{(R)-2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Ferrocenyl}Ethyldicyclo is a highly specialized chiral ferrocenyl phosphine ligand, a critical component in asymmetric catalysis. This compound is valued for its ability to impart exceptional enantioselectivity and high catalytic activity in transition metal-catalyzed reactions, directly impacting the efficiency and cost-effectiveness of fine chemical synthesis. It is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control for manufacturing chiral intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for producing single-enantiomer pharmaceutical building blocks.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, allylic substitutions, and other C-C bond-forming processes to create complex chiral molecules with high optical purity.
• Pharmaceutical Intermediate Synthesis: Key catalyst component in the production of chiral active pharmaceutical ingredients (APIs) for cardiovascular, central nervous system, and oncological therapeutics.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental load.
• Fine Chemical and Flavor/Fragrance Production: Facilitates the creation of high-value chiral compounds for specialty chemicals, flavors, and fragrances.
• Academic and Industrial R&D: A vital tool for method development and discovery chemistry in laboratories focused on advancing catalytic methodologies.

Basic Information

Product Name	(S)-1-{(R)-2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Ferrocenyl}Ethyldicyclo
CAS No.	849923-88-2
Molecular Formula	C41H45FeO2P
Molecular Weight	656.61 g/mol
Synonyms	(S)-1-[(R)-2-[Bis(4-methoxy-3,5-dimethylphenyl)phosphino]ferrocenyl]ethyldicyclohexylphosphine; Josiphos SL-J009-1; SL-J009-1; (S)-1-((R)-2-(Bis(4-methoxy-3,5-dimethylphenyl)phosphino)ferrocenyl)ethyldicyclohexylphosphine; (S)-1-[(R)-2-(Di(3,5-dimethyl-4-methoxyphenyl)phosphino)ferrocenyl]ethyldicyclohexylphosphine; Chiral Ferrocenyl Josiphos Ligand; (S,R)-Josiphos Derivative
EINECS	Contact for details

Quality Control

Our production of (S)-1-{(R)-2-[Bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino]Ferrocenyl}Ethyldicyclo adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with every shipment, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and catalytic performance.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.