Description

2-Benzyloxy-4-Fluorophenylboronic Acid is a high-purity boronic acid derivative serving as a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to synthesize complex fluorinated and benzyl-protected aromatic structures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the benzyloxy and fluorine substituents impart specific biological activity.
• Ligand & Catalyst Development: Serves as a starting material for constructing sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Building block for organic electronic materials, such as OLEDs and semiconductors, where fluorinated phenylboronic acids modify electronic properties.
• Chemical Biology & Probe Synthesis: Utilized in creating molecular probes and bioconjugates for studying biological processes and diagnostics.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses and CROs/CMOs serving the life sciences sector.

Basic Information

Product Name	2-Benzyloxy-4-Fluorophenylboronic Acid
CAS No.	848779-87-3
Molecular Formula	C₁₃H₁₂BFO₃
Molecular Weight	246.05 g/mol
Synonyms	(2-(Benzyloxy)-4-fluorophenyl)boronic acid; 4-Fluoro-2-(phenylmethoxy)benzeneboronic acid; 2-(Benzyloxy)-4-fluorobenzeneboronic acid; B-[2-(Benzyloxy)-4-fluorophenyl]boronic acid; 848779-87-3; 2-Benzyloxy-4-fluorophenylboronic acid pinacol ester (common derivative); 2-(Benzyloxy)-4-fluorophenyl-B(OH)₂
EINECS	Contact for details

Quality Control

Our 2-Benzyloxy-4-Fluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, ¹H/¹³C NMR and IR for structural confirmation, and KF titration for moisture content. We provide full traceability and Certificates of Analysis (COA) are available upon request, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.