Description

n-Carbobenzoxy-L-tert-Leucinol is a protected amino alcohol derivative, specifically a Cbz-protected tert-leucinol, serving as a crucial chiral building block in advanced organic synthesis. This high-purity intermediate is valued for its role in introducing the sterically hindered and stereochemically defined tert-leucine side chain, which is essential for modulating the biological activity and physicochemical properties of target molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, protease inhibitors, and other bioactive compounds where structural rigidity and metabolic stability are critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer drugs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate the tert-leucine residue, enhancing peptide stability and bioavailability.
• Protease Inhibitor Development: Essential for constructing the core scaffolds of inhibitors targeting enzymes like HIV protease and HCV NS3/4A protease.
• Asymmetric Synthesis: Serves as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce high enantioselectivity.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of bulky, hydrophobic amino acid analogs on drug potency and selectivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex, non-natural amino acid derivatives under cGMP conditions where required.

Basic Information

Product Name	n-Carbobenzoxy-L-tert-Leucinol
CAS No.	848777-16-2
Molecular Formula	C14H21NO3
Molecular Weight	251.32 g/mol
Synonyms	(S)-2-(((Benzyloxy)carbonyl)amino)-3,3-dimethylbutan-1-ol; L-tert-Leucinol, N-carbobenzoxy-; N-Cbz-L-tert-leucinol; (S)-N-Cbz-3,3-Dimethyl-2-aminobutanol; N-[(Benzyloxy)carbonyl]-L-tert-leucinol; Cbz-L-tert-Leucinol; Z-L-tert-Leucinol; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylbutan-1-ol (related Fmoc-protected variant)
EINECS	Contact for details

Quality Control

Our n-Carbobenzoxy-L-tert-Leucinol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. While produced to meet high-grade standards, specific certifications such as cGMP can be supported for pharmaceutical development projects upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.