Description

(2S)-2-[3-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanamido]-4-Methylpentanoic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block, enabling the precise and efficient construction of complex peptide chains under standard Fmoc solid-phase peptide synthesis (SPPS) conditions. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential addition of leucine or structurally modified amino acids in Fmoc-based peptide assembly.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs, including hormones, enzyme inhibitors, and targeted therapeutics.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation: Acts as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carrier proteins.
• Process Development: Serves as a reference standard and raw material for scaling up GMP-grade peptide API manufacturing processes.

Basic Information

Product Name	(2S)-2-[3-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanamido]-4-Methylpentanoic Acid
CAS No.	848691-83-8
Molecular Formula	C24H26N2O5
Molecular Weight	422.48 g/mol
Synonyms	Fmoc-β-Ala-Leu-OH; Fmoc-β-Ala-L-Leucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanyl-L-leucine; Nα-Fmoc-Nβ-L-leucyl-β-alanine; Fmoc-βAla-Leu; (2S)-2-[[3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-1-oxopropyl]amino]-4-methylpentanoic acid; Fmoc-β-Alanine-L-Leucine
EINECS	Contact for details

Quality Control

Our production of (2S)-2-[3-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanamido]-4-Methylpentanoic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.