Description

(R)-1-n-Boc-Pipecolamide is a high-purity chiral building block and pharmaceutical intermediate of significant importance in modern organic synthesis. Its value lies in providing a protected, stereochemically defined pipecolic acid derivative, which is a crucial scaffold for developing bioactive molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel drug candidates, particularly in areas like protease inhibitors and neurological therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Used as a core building block for constructing inhibitors targeting various proteases.
• Peptidomimetics: Serves as a constrained amino acid analog in the design of peptide-like compounds with enhanced metabolic stability.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (R)-pipecolamide moiety into complex molecular architectures.
• Medicinal Chemistry Research: Utilized in lead optimization and structure-activity relationship (SAR) studies for neurological and antiviral targets.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high enantiomeric purity.

Basic Information

Product Name	(R)-1-n-Boc-Pipecolamide
CAS No.	848488-91-5
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)piperidine-2-carboxamide; (R)-N-Boc-pipecolic acid amide; (R)-1-Boc-2-piperidinecarboxamide; (R)-2-Carbamoylpiperidine-1-carboxylic acid tert-butyl ester; (R)-Piperidine-2-carboxamide, 1-[(1,1-dimethylethoxy)carbonyl]-; tert-Butyl (R)-2-carbamoylpiperidine-1-carboxylate; (R)-1-Boc-pipecolamide
EINECS	Contact for details

Quality Control

Our (R)-1-n-Boc-Pipecolamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and purity assays. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.