Description

Compound 48/80 (Hydrochloride) is a well-characterized synthetic polymer of p-methoxy-N-methylphenethylamine, widely recognized as a potent and non-cytotoxic histamine liberator. Its primary value lies in its reliable and consistent ability to induce mast cell degranulation, making it an indispensable pharmacological tool for research. This compound is essential for scientists and professionals in pharmaceutical R&D, immunology, and preclinical studies focused on allergy, inflammation, and mast cell biology.

Application

• Mast Cell Research: Standard positive control for inducing and studying mast cell degranulation, histamine release, and allergic response mechanisms in vitro and ex vivo.
• Immunology & Allergy Models: Used to establish experimental models of anaphylaxis, urticaria, and other hypersensitivity reactions in laboratory animals.
• Drug Discovery & Screening: Critical tool for evaluating the efficacy of new anti-allergic, anti-inflammatory, and mast cell-stabilizing drug candidates.
• Biochemical Assay Development: Serves as a reference standard in assay kits and protocols designed to measure histamine release or mast cell activity.
• Pharmacology Studies: Employed to investigate receptor-independent pathways of cellular activation and calcium influx.
• Quality Control in Diagnostics: Used in the calibration and validation of diagnostic tests related to allergic diseases.

Basic Information

Product Name	Compound 48/80 (Hydrochloride)
CAS No.	848035-21-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Compound 48/80; Poly(p-methoxyphenethylmethylamine); Mastoparan; Histamine Liberator 48/80; N-Methyl-p-methoxyphenethylamine Polymer; p-Methoxy-N-methylphenethylamine Polymer; Condensation Polymer of N-Methyl-p-methoxyphenethylamine; C48/80
EINECS	Contact for details

Quality Control

Our Compound 48/80 (Hydrochloride) is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assessment, and biological activity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content	≤ 5.0%
Residue on Ignition	≤ 1.0%
Biological Activity	Induces mast cell degranulation (Reference standard provided)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.