Description

Fmoc-(R)-3-Amino-2-(tert-Butoxymethyl)Propanoic Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for the solid-phase synthesis of complex peptides and peptidomimetics, offering superior chiral purity and side-chain protection. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, APIs, and biochemical probes. The product ensures reliable performance in automated synthesizers, supporting innovation in drug discovery and biotechnology.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel peptide-based Active Pharmaceutical Ingredients (APIs) and therapeutic candidates.
• Solid-Phase Peptide Synthesis (SPPS): Specifically engineered for use in Fmoc-based SPPS protocols to introduce a protected, branched-chain amino acid residue.
• Peptidomimetic Research: Facilitates the development of peptidomimetics with enhanced metabolic stability and bioavailability for drug discovery programs.
• Bioconjugation & Probe Development: Used in the creation of labeled peptides, affinity tags, and molecular probes for biochemical and diagnostic applications.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to identify new bioactive compounds.
• Academic & Industrial R&D: Supports fundamental research in organic chemistry, medicinal chemistry, and structural biology.

Basic Information

Product Name	Fmoc-(R)-3-Amino-2-(tert-Butoxymethyl)Propanoic Acid
CAS No.	847153-42-8
Molecular Formula	C23H27NO5
Molecular Weight	397.47 g/mol
Synonyms	Fmoc-(R)-3-Amino-2-((tert-butoxy)methyl)propanoic acid; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butoxy)methyl)propanoic acid; Fmoc-D-3-Amino-2-(tert-butoxymethyl)propionic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-2-(tert-butoxymethyl)-(R)-propionic Acid; Fmoc-D-Amp(Bum)-OH; Fmoc-(R)-Amp(Bum)-OH; Nα-Fmoc-Nγ-Bum-(R)-2,3-diaminopropionic acid
EINECS	Contact for details

Quality Control

Every batch of Fmoc-(R)-3-Amino-2-(tert-Butoxymethyl)Propanoic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure compliance with exacting industry standards for peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are available for every lot upon request, providing full traceability and quality assurance for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.