Description

1-Chloro-2-Iodo-4-Trifluoromethoxybenzene is a high-value, multi-halogenated aromatic building block designed for advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring precise molecular architecture in complex organic synthesis. It is primarily utilized in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials, serving the needs of the pharmaceutical, agrochemical, and advanced materials industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating complex molecules with trifluoromethoxy and halogen substituents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the halogenated structure contributes to biological activity and stability.
• Ligand and Catalyst Development: Serves as a sophisticated building block for constructing specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and polymers where halogen and fluorinated groups modify electronic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings due to the reactive iodine and chlorine atoms.
• Chemical Biology Probes: Used to create tagged molecules or probes for studying biological systems and mechanisms.

Basic Information

Product Name	1-Chloro-2-Iodo-4-Trifluoromethoxybenzene
CAS No.	845866-91-3
Molecular Formula	C7H3ClF3IO
Molecular Weight	321.45 g/mol
Synonyms	2-Chloro-1-Iodo-4-(trifluoromethoxy)benzene; 4-Chloro-3-Iodo(trifluoromethoxy)benzene; 1-Chloro-2-iodo-4-(trifluoromethoxy)benzene; Benzene, 1-chloro-2-iodo-4-(trifluoromethoxy)-; 4-Trifluoromethoxy-2-chloroiodobenzene; 2-Chloro-4-(trifluoromethoxy)iodobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-Iodo-4-Trifluoromethoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical research and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.