Description

3,3,3-Trifluoropropane-1-Sulfonyl Chloride is a specialized organofluorine building block characterized by its reactive sulfonyl chloride group and trifluoromethyl moiety. This compound is highly valued for its role as a key intermediate in the synthesis of advanced materials and bioactive molecules, enabling the introduction of sulfonamide or sulfonate functionalities. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by material scientists developing specialty polymers and functional surfaces.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of sulfonamide-based drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Serves as a monomer or cross-linking agent for producing fluorinated polymers with unique surface properties, chemical resistance, and durability.
• Ligand and Catalyst Development: Employed to create novel sulfonyl-containing ligands for catalysis and molecular recognition applications.
• Chemical Biology Probes: Utilized in the design of activity-based probes and labeling reagents for studying enzyme function and protein interactions.
• Fluorinated Surfactant Precursor: Acts as a key starting material for synthesizing specialty surfactants and surface modifiers.

Basic Information

Product Name	3,3,3-Trifluoropropane-1-Sulfonyl Chloride
CAS No.	845866-80-0
Molecular Formula	C3H4ClF3O2S
Molecular Weight	196.57 g/mol
Synonyms	3,3,3-Trifluoropropanesulfonyl chloride; 1-Propanesulfonyl chloride, 3,3,3-trifluoro-; 3,3,3-Trifluoropropylsulfonyl chloride; 3,3,3-Trifluoro-1-propanesulfonyl chloride; Trifluoropropanesulfonyl chloride; TFPS-Cl; 845866-80-0 (CAS)
EINECS	Contact for details

Quality Control

Our 3,3,3-Trifluoropropane-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and identity. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality parameters. Our commitment to consistent quality and traceability supports your R&D and scale-up processes with reliable material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.