Description

3'-Chloro-2,2,2,5'-Tetrafluoroacetophenone is a high-purity fluorinated aromatic ketone building block, identified by CAS NO 845823-07-6. This compound is valued for its unique molecular structure, which combines a reactive carbonyl group with halogenated substituents, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated and chlorinated aromatic motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorinated phenyl group enhances biological activity and stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials.
• Organic Synthesis: Employed in cross-coupling reactions, Grignard reactions, and as a substrate for further functionalization in medicinal chemistry.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3'-Chloro-2,2,2,5'-Tetrafluoroacetophenone
CAS No.	845823-07-6
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	1-(3-Chloro-2,5-difluorophenyl)-2,2,2-trifluoroethanone; 3-Chloro-2,5-difluorophenyl trifluoromethyl ketone; 2,2,2-Trifluoro-1-(3-chloro-2,5-difluorophenyl)ethanone; 1-(3-Chloro-2,5-difluorophenyl)-2,2,2-trifluoroethan-1-one; 3'-Chloro-2,2,2,5'-tetrafluoro acetophenone; 845823-07-6; α,α,α-Trifluoro-3-chloro-2,5-difluoroacetophenone
EINECS	Contact for details

Quality Control

Our 3'-Chloro-2,2,2,5'-Tetrafluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in cGMP-compliant environments and research requiring the highest material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.