Description

3'-Fluoro-4'-Methyl-2,2,2-Trifluoroacetophenone is a high-purity fluorinated aromatic ketone building block of significant synthetic utility. This compound matters for its role as a versatile intermediate in the development of advanced pharmaceuticals and agrochemicals, where its unique trifluoromethyl and fluorine substituents impart desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Employed in the synthesis of specialty polymers and coatings with enhanced chemical resistance and thermal stability.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for creating complex biaryl systems.
• Chemical Research & Development: A crucial reagent for method development and exploring new fluorination chemistry in academic and industrial laboratories.

Basic Information

Product Name	3'-Fluoro-4'-Methyl-2,2,2-Trifluoroacetophenone
CAS No.	845823-06-5
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	1-(3-Fluoro-4-methylphenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(3-fluoro-4-methylphenyl)ethanone; 3-Fluoro-4-methyl-α,α,α-trifluoroacetophenone; 3'-Fluoro-4'-methyl-2,2,2-trifluoroacetophenone; 845823-06-5; 1-(3-Fluoro-4-methylphenyl)-2,2,2-trifluoro-1-ethanone
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-4'-Methyl-2,2,2-Trifluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and lot-to-lot consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly closed and stored in a dry atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.