Description

3'-Chloro-2,2,2,4'-Tetrafluoroacetophenone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its unique structure, featuring both chloro and tetrafluoro substitutions, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides with enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic display technologies.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to impart specific thermal and chemical resistance to high-performance polymers.
• Organic Synthesis Research: A versatile reagent for introducing both chlorine and fluorine atoms in complex molecule construction via cross-coupling and nucleophilic substitution reactions.

Basic Information

Product Name	3'-Chloro-2,2,2,4'-Tetrafluoroacetophenone
CAS No.	845823-05-4
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	1-(3-Chloro-4-fluorophenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(3-chloro-4-fluorophenyl)ethanone; 3-Chloro-4-fluorophenacyl trifluoride; 3'-Chloro-4'-fluoro-α,α,α-trifluoroacetophenone; 1-(3-Chloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one; α,α,α-Trifluoro-3'-chloro-4'-fluoroacetophenone; 3-Chloro-4-fluorophenyl trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our 3'-Chloro-2,2,2,4'-Tetrafluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with each shipment to guarantee batch-to-batch consistency for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.