Description

1,2,4-Trifluoro-5-(Methylsulfonyl)Benzene is a high-value fluorinated aromatic building block characterized by its unique combination of fluorine atoms and a methylsulfonyl substituent. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where its structure imparts desirable metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl and sulfone groups enhance biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine and sulfone functionalities into specialty polymers to alter thermal stability, chemical resistance, and surface properties.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: Essential for academic and industrial research in medicinal chemistry and material science for exploring new chemical entities.

Basic Information

Product Name	1,2,4-Trifluoro-5-(Methylsulfonyl)Benzene
CAS No.	845616-49-1
Molecular Formula	C7H5F3O2S
Molecular Weight	218.17 g/mol
Synonyms	5-(Methylsulfonyl)-1,2,4-trifluorobenzene; 1,2,4-Trifluoro-5-(methanesulfonyl)benzene; Benzene, 1,2,4-trifluoro-5-(methylsulfonyl)-; 845616-49-1; 5-Methanesulfonyl-1,2,4-trifluorobenzene; 1,2,4-Trifluoro-5-methylsulfonylbenzene
EINECS	Contact for details

Quality Control

Our 1,2,4-Trifluoro-5-(Methylsulfonyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.