Description

n-(3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide CAS NO 844501-35-5 is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is a critical building block in modern synthetic chemistry, enabling efficient cross-coupling reactions for the construction of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for the palladium-catalyzed formation of carbon-carbon bonds, essential for constructing biaryl structures in drug candidates.
• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex target molecules for preclinical and clinical research.
• Medicinal Chemistry & Drug Discovery: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Chemical Biology Research: Employed in the synthesis of probes and labeled compounds for studying biological pathways and target engagement.
• Agrochemical Synthesis: Potential intermediate in the development of advanced crop protection agents with novel modes of action.
• Material Science Research: Can be utilized in the synthesis of organic electronic materials and functional polymers requiring specific fluorinated aromatic units.

Basic Information

Product Name	n-(3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide
CAS No.	844501-35-5
Molecular Formula	C14H19BFNO3
Molecular Weight	279.12 g/mol
Synonyms	N-[3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; Acetamide, N-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide; 2-Fluoro-4-acetamidophenylboronic acid pinacol ester; 4-Acetamido-2-fluorophenylboronic acid pinacol ester; 844501-35-5; Borate ester intermediate 844501-35-5
EINECS	Contact for details

Quality Control

Our production of n-(3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical research and development applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods including HPLC, NMR, and MS. We support cGMP compliance for advanced intermediates and can provide stability data to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.