Description

o-Ethyl (5-Bromoquinoxalin-6-Yl)Carbamothioate (Brimonidine Impurity) is a high-purity chemical reference standard critical for pharmaceutical research and development. This compound serves as a key impurity standard for the quality control and analytical validation of Brimonidine, a widely used active pharmaceutical ingredient (API). It is essential for laboratories and manufacturers requiring precise identification, quantification, and monitoring of this specific impurity to ensure drug safety and regulatory compliance. This product is primarily targeted at the pharmaceutical, analytical chemistry, and contract research organization (CRO) sectors.

Application

• Pharmaceutical Impurity Reference Standard: Primary use as a certified reference material (CRM) for the identification and quantification of impurities in Brimonidine API and its formulations.
• Analytical Method Development & Validation: Critical for developing, validating, and verifying HPLC, UPLC, and LC-MS methods in quality control laboratories.
• Regulatory Compliance & Documentation: Supports regulatory filings (e.g., FDA, EMA) by providing necessary impurity profiles and stability study data for drug master files (DMFs).
• Pharmacopeial Standards: Used in testing to meet the stringent purity requirements outlined in pharmacopeias such as USP, EP, and BP for Brimonidine.
• Stability Studies: Employed in forced degradation and long-term stability studies to understand the degradation pathways of Brimonidine.
• Research & Development: Utilized in synthetic chemistry R&D for studying the metabolism, synthesis pathways, and impurity fate of quinoxaline derivatives.

Basic Information

Product Name	o-Ethyl (5-Bromoquinoxalin-6-Yl)Carbamothioate (Brimonidine Impurity)
CAS No.	842138-75-4
Molecular Formula	C₁₁H₁₀BrN₃OS
Molecular Weight	312.18 g/mol
Synonyms	5-Bromoquinoxaline-6-carbothioic acid O-ethyl ester; Brimonidine Impurity; Brimonidine Related Compound; Ethyl 5-bromoquinoxaline-6-carbamothioate; 5-Bromo-6-[(ethoxycarbonothioyl)amino]quinoxaline; Quinoxaline-6-carbothioic acid, 5-bromo-, O-ethyl ester; Brimonidine Process Impurity
EINECS	Contact for details

Quality Control

Every batch of o-Ethyl (5-Bromoquinoxalin-6-Yl)Carbamothioate is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency meet the high standards required for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results. We support compliance with cGMP, ICH Q3A/B guidelines, and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool, and well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.