Description

1-Chloro-3-Fluoro-2-(1,3-Dioxolan-2-Ylmethyl)Benzene is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated benzene core protected with a dioxolane functional group. This compound matters for its critical role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs) and agrochemicals, where its specific substitution pattern enables precise molecular construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce halogenated aromatic motifs with orthogonal reactivity.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery and development, particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of modern herbicides and fungicides, leveraging the halogen atoms for bioactivity and the protecting group for selective derivatization.
• Ligand and Catalyst Development: Used in research to create novel ligands for transition metal catalysis, where the halogen and ether functionalities can influence metal coordination and catalytic activity.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of specialty polymers and advanced organic electronic materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	1-Chloro-3-Fluoro-2-(1,3-Dioxolan-2-Ylmethyl)Benzene
CAS No.	842124-01-0
Molecular Formula	C10H10ClFO2
Molecular Weight	216.64 g/mol
Synonyms	2-(2-Chloro-6-fluorobenzyl)-1,3-dioxolane; 1,3-Dioxolane, 2-[(2-chloro-6-fluorophenyl)methyl]-; Benzene, 1-chloro-3-fluoro-2-(1,3-dioxolan-2-ylmethyl)-; (2-Chloro-6-fluorobenzyl)-1,3-dioxolane; 2-[(2-Chloro-6-fluorophenyl)methyl]-1,3-dioxolane; 1-Chloro-3-fluoro-2-(1,3-dioxolan-2-ylmethyl)benzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-3-Fluoro-2-(1,3-Dioxolan-2-Ylmethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with exacting standards for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.