Description

2-((tert-Butoxycarbonyl)Amino)Cyclobutane-1-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for constructing complex molecular architectures, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for constrained peptides and macrocycles.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the constrained cyclobutane amino acid motif, which can enhance metabolic stability and conformational rigidity.
• Chemical Biology Research: Employed in the synthesis of custom amino acids and probes to study protein structure, function, and protein-protein interactions.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies by providing a versatile scaffold for introducing sterically defined, functionalized amino acid residues.
• Agrochemical Research: Potential application as an intermediate in the synthesis of bioactive compounds with novel modes of action.

Basic Information

Product Name	2-((tert-Butoxycarbonyl)Amino)Cyclobutane-1-Carboxylic Acid
CAS No.	841202-83-3
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	Boc-ACBC-OH; (1S,2S)-2-[(tert-Butoxycarbonyl)amino]cyclobutane-1-carboxylic acid; (1R,2R)-2-[(tert-Butoxycarbonyl)amino]cyclobutane-1-carboxylic acid; 2-(Boc-amino)cyclobutane-1-carboxylic acid; 1-Cyclobutanecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-; trans-2-((tert-Butoxycarbonyl)amino)cyclobutane-1-carboxylic acid; (1S,2S)-2-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid; (1R,2R)-2-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid
EINECS	Contact for details

Quality Control

Our 2-((tert-Butoxycarbonyl)Amino)Cyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (specify isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.