Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, Mono(1-Methylethyl) Ester is a key intermediate in the synthesis of advanced macrocyclic chelating agents, particularly DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) derivatives. This compound matters for its role in creating functionalized chelators used to bind diagnostic and therapeutic radiometals, such as gadolinium, lutetium, and yttrium. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and medical imaging sectors developing next-generation contrast agents and radiopharmaceuticals.

Application

• Pharmaceutical Intermediate: Critical building block for synthesizing DOTA-based bifunctional chelators (BFCs) used in targeted drug delivery systems.
• Radiopharmaceuticals: Precursor for chelators that complex therapeutic radioisotopes (e.g., Lu-177, Y-90) for cancer treatment (Targeted Radionuclide Therapy).
• MRI Contrast Agents: Used in the development of gadolinium(III)-based contrast agents for magnetic resonance imaging (MRI).
• Diagnostic Imaging Probes: Enables the creation of chelators for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging agents.
• Chemical Research: Serves as a versatile scaffold in coordination chemistry and supramolecular chemistry research.
• Bioconjugation: The ester group provides a handle for further chemical modification and conjugation to antibodies, peptides, or other targeting molecules.

Basic Information

Item	Details
Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid, Mono(1-Methylethyl) Ester
CAS No.	840519-32-6
Molecular Formula	C21H36N4O9
Molecular Weight	488.53 g/mol
Synonyms	DOTA-tris(t-butyl ester) mono(isopropyl ester); 2-[4,7,10-Tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid 1-methylethyl ester; DOTA-tris(t-Bu ester)-mono(iPr ester); H3dotatBu3iPr; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid tris(1,1-dimethylethyl) 1-(1-methylethyl) ester; DOTA derivative; Macrocyclic chelator intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and mass spectrometry to ensure structural integrity and high purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, identity, and impurity profile. We support development and cGMP manufacturing needs with consistent, reliable quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.