Description

4,4-Difluoro-1-(3-Methoxy-Phenyl)-Butane-1,3-Dione is a specialized fluorinated diketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is a critical strategy for modulating biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists working on novel active ingredients, heterocyclic compounds, and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing fluorinated active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring enhanced metabolic stability and bioavailability.
• Agrochemical Research: Serves as a key precursor in the development of novel herbicides, fungicides, and insecticides, where fluorine substitution is used to improve efficacy and environmental profile.
• Material Science: Used in the synthesis of fluorinated organic compounds for advanced materials, including liquid crystals, polymers, and electronic chemicals.
• Chemical Synthesis: Acts as a versatile reagent for constructing complex heterocyclic frameworks, such as pyrazoles and isoxazoles, via cyclocondensation reactions.
• Academic & R&D: An important tool for methodological development in organic chemistry, particularly in studies involving fluorination, diketone chemistry, and cross-coupling reactions.

Basic Information

Product Name	4,4-Difluoro-1-(3-Methoxy-Phenyl)-Butane-1,3-Dione
CAS No.	832740-76-8
Molecular Formula	C11H10F2O3
Molecular Weight	228.19 g/mol
Synonyms	1-(3-Methoxyphenyl)-4,4-difluorobutane-1,3-dione; 4,4-Difluoro-1-(3-methoxyphenyl)-1,3-butanedione; 3-Methoxyphenyl 4,4-difluoro-3-oxobutyl ketone; 4,4-Difluoro-3-oxo-1-(3-methoxyphenyl)butan-1-one; 3'-Methoxy-4,4-difluorodibenzoylmethane (less common); DFMPB (abbreviation); 832740-76-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1-(3-Methoxy-Phenyl)-Butane-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO standards for pharmaceutical and industrial applications, ensuring full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.