Description

1-(3-Difluoromethoxy-Phenyl)-4,4,4-Trifluoro-Butane-1,3-Dione is a high-purity fluorinated diketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industrial and R&D chemists need it for constructing active pharmaceutical ingredients (APIs), crop protection agents, and novel materials where the introduction of fluorine atoms and a reactive 1,3-diketone moiety is critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for synthesizing novel drug candidates, especially in areas targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy and trifluoromethyl groups enhance bioavailability and environmental stability.
• Material Science Research: Acts as a precursor for developing specialty polymers, ligands for catalysis, and organic electronic materials due to its unique electronic properties imparted by fluorine.
• Chemical Synthesis: Functions as a versatile reagent for heterocyclic chemistry, enabling the construction of pyrazoles, isoxazoles, and other nitrogen-containing rings through condensation reactions.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on understanding and applying organofluorine chemistry principles.

Basic Information

Item	Details
Product Name	1-(3-Difluoromethoxy-Phenyl)-4,4,4-Trifluoro-Butane-1,3-Dione
CAS No.	832740-74-6
Molecular Formula	C11H7F5O3
Molecular Weight	282.16 g/mol
Synonyms	3'-Difluoromethoxy-4,4,4-trifluoro-1-phenyl-1,3-butanedione; 4,4,4-Trifluoro-1-(3-difluoromethoxyphenyl)butane-1,3-dione; 1-(3-(Difluoromethoxy)phenyl)-4,4,4-trifluorobutane-1,3-dione; 3-(Difluoromethoxy)-ω,ω,ω-trifluoroacetophenone; DFMP-TFBD; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1-(3-Difluoromethoxy-Phenyl)-4,4,4-Trifluoro-Butane-1,3-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound is light-sensitive (store away from light) as indicated. Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.