Description

2-Chloro-n-(2,3,5,6-Tetrafluoro-Phenyl)-Acetamide is a specialized fluorinated acetamide derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its core value lies in the unique reactivity imparted by the combination of a chloroacetyl group and a highly fluorinated aromatic ring, enabling precise molecular construction. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex fluorinated target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in areas targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for fluorinated polymers and liquid crystals, contributing to materials with unique thermal, chemical, and surface properties.
• Chemical Biology Probes: Employed in the creation of fluorinated probes and tags for studying biological mechanisms and protein interactions.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to form complex nitrogen-containing compounds.
• Nucleophilic Substitution: The chloroacetyl group is reactive towards various nucleophiles, allowing for the introduction of diverse amine and heterocyclic functionalities.

Basic Information

Product Name	2-Chloro-n-(2,3,5,6-Tetrafluoro-Phenyl)-Acetamide
CAS No.	832675-11-3
Molecular Formula	C8H4ClF4NO
Molecular Weight	241.57 g/mol
Synonyms	2-Chloro-N-(2,3,5,6-tetrafluorophenyl)acetamide; N-(2,3,5,6-Tetrafluorophenyl)-2-chloroacetamide; 2-Chloroacetamide, N-(2,3,5,6-tetrafluorophenyl)-; α-Chloro-2,3,5,6-tetrafluoroacetanilide; Tetrafluoro Chloroacetanilide; 832675-11-3; Acetamide, 2-chloro-N-(2,3,5,6-tetrafluorophenyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-n-(2,3,5,6-Tetrafluoro-Phenyl)-Acetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure consistency and compliance with customer specifications. Certificates of Analysis (COA) detailing all relevant parameters are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.