Description

L-Alanine, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-, methyl ester is a specialized, high-purity amino acid derivative designed for advanced synthetic chemistry. This compound matters as a critical building block in solid-phase peptide synthesis (SPPS), offering precise control over peptide chain assembly. It is primarily needed by pharmaceutical R&D teams, biotech companies, and academic research laboratories developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid derivative for the controlled, sequential construction of complex peptide sequences.
• Pharmaceutical Intermediate: In the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation & Labeling: For the site-specific modification of peptides and proteins with fluorophores or other functional groups.
• Combinatorial Chemistry: As a key component in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial Research: For fundamental studies in organic chemistry, biochemistry, and medicinal chemistry.
• Production of Custom Peptides: Used by CROs and CDMOs in the contract manufacturing of specialized peptides for clients.

Basic Information

Product Name	L-Alanine, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-, methyl ester
CAS No.	832127-84-1
Molecular Formula	C21H21NO5
Molecular Weight	367.40 g/mol
Synonyms	Fmoc-N-Me-Ala-OMe; Fmoc-N-methyl-L-alanine methyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanine methyl ester; N-Fmoc-N-methyl-L-alanine methyl ester; Methyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alaninate; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]propanoic acid methyl ester; Fmoc-N-Me-Ala-Me; Nα-Fmoc-Nα-methyl-L-alanine methyl ester
EINECS	Contact for details

Quality Control

Our L-Alanine, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-, methyl ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for pharmaceutical research. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.