Description

(Alphas,Alphas)-1,1'-Bis[α-(Dimethylamino)Benzyl]-(R,R)-2,2'-Bis[Bis(2-Methylphenyl)Phosphino]Ferrocene is a highly specialized, chiral ferrocenyl diphosphine ligand designed for asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in critical carbon-carbon bond-forming reactions, directly impacting the efficiency and purity of advanced chemical synthesis. This product is essential for R&D chemists and process engineers in the pharmaceutical and fine chemical industries who require precise stereochemical control for manufacturing active pharmaceutical ingredients (APIs) and complex organic intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for producing chiral alcohols and amines in pharmaceutical synthesis.
• Asymmetric C-C Bond Formation: Catalyzes key reactions such as asymmetric allylic alkylation, hydroformylation, and cross-coupling to construct complex molecular architectures with high optical purity.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer intermediates for cardiovascular, neurological, and oncological therapeutics.
• Agrochemical Manufacturing: Used in the synthesis of chiral pesticides and herbicides where specific stereochemistry is required for biological activity and environmental safety.
• Process Development & Optimization: Serves as a critical tool for chemical development teams scaling up laboratory routes to robust, cost-effective commercial manufacturing processes.
• Academic & Industrial Research: A valuable reagent for exploring new catalytic methodologies and developing novel chiral compounds in both academic and corporate R&D settings.

Basic Information

Item	Details
Product Name	(Alphas,Alphas)-1,1'-Bis[α-(Dimethylamino)Benzyl]-(R,R)-2,2'-Bis[Bis(2-Methylphenyl)Phosphino]Ferrocene
CAS No.	831226-39-2
Molecular Formula	C58H58FeN2P2
Molecular Weight	877.88 g/mol
Synonyms	(R,R)-Bis(α-(Dimethylamino)benzyl)-2,2'-bis(bis(2-methylphenyl)phosphino)ferrocene; Josiphos SL-J009-1 Type Ligand; Chiral Josiphos Derivative; (R,R)-Ferrocenyl Diphosphine Ligand J009; (R,R)-1,1'-Bis(α-(Dimethylamino)benzyl)-2,2'-bis(di-o-tolylphosphino)ferrocene; (R,R)-[2,2'-Bis(di-o-tolylphosphino)-1,1'-bis(α-(dimethylamino)benzyl)]ferrocene
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced and tested under strict quality management protocols to ensure consistent high performance in sensitive catalytic applications. We guarantee a typical purity of ≥97% (HPLC), with rigorous chiral purity verification. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, enantiomeric excess, and residual solvent levels. Our quality systems support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.