Description

(R)-(+)-4-[2-(Diphenylphosphino)-1-Naphthalenyl]-n-[-1-Phenylethyl]-1-Phthalazinamine, Min.(R)-n-Pinap CAS NO 828927-97-5 is a high-value, chiral monodentate phosphine ligand designed for asymmetric catalysis. This compound is critical for enabling highly enantioselective transformations, providing researchers and process chemists with a powerful tool to control stereochemistry in complex synthetic pathways. It is primarily sought after by the pharmaceutical, agrochemical, and fine chemical industries for the development of chiral active pharmaceutical ingredients (APIs) and other high-value intermediates.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical synthesis.
• Cross-Coupling Reactions: Employed in asymmetric versions of Suzuki-Miyaura, Heck, and other C-C bond-forming reactions.
• Process Chemistry & Scale-Up: Used in the development and optimization of commercial-scale manufacturing routes for chiral molecules.
• Academic & Industrial R&D: A valuable reagent for discovering new catalytic methodologies and exploring novel chemical space.
• Agrochemical Synthesis: Applied in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: Potential use in the synthesis of chiral polymers or advanced materials with specific optical properties.

Basic Information

Product Name	(R)-(+)-4-[2-(Diphenylphosphino)-1-Naphthalenyl]-n-[-1-Phenylethyl]-1-Phthalazinamine, Min.(R)-n-Pinap
CAS No.	828927-97-5
Molecular Formula	C₄₀H₃₂N₃P
Molecular Weight	585.68 g/mol
Synonyms	(R)-n-Pinap; (R)-4-[2-(Diphenylphosphino)-1-naphthyl]-N-[(1R)-1-phenylethyl]phthalazin-1-amine; (R)-N-[(1R)-1-Phenylethyl]-4-[2-(diphenylphosphino)-1-naphthalenyl]-1-phthalazinamine; (R,R)-n-Pinap; (R,R)-Pinap; (R)-n-PINAP; (R)-PINAP ligand; (R)-4-[2-(Diphenylphosphino)-1-naphthyl]-N-[(R)-1-phenylethyl]phthalazin-1-amine
EINECS	Contact for details

Quality Control

Our (R)-n-Pinap is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for catalytic performance. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identity confirmation. We adhere to cGMP principles where applicable and can provide material to meet specific research or development project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.