Description

(S)-(-)-4-[2-(Diphenylphosphino)-1-Naphthalenyl]-n-[-1-Phenylethyl]-1-Phthalazinamine, (S)-n-Pinap is a high-value, chiral monodentate phosphine ligand crucial for asymmetric catalysis. This compound matters because it enables highly enantioselective transformations, a critical requirement for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as asymmetric hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation Catalyst Ligand: For the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Cross-Coupling Reactions: As a ligand in palladium-catalyzed Suzuki-Miyaura, Buchwald-Hartwig, and other C-C/C-N bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Key chiral auxiliary in the production of enantiomerically pure drug candidates and final active ingredients.
• Agrochemical Research: Development of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research.
• Fine Chemical Manufacturing: Production of high-value chiral flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	(S)-(-)-4-[2-(Diphenylphosphino)-1-Naphthalenyl]-n-[-1-Phenylethyl]-1-Phthalazinamine, (S)-n-Pinap
CAS No.	828927-96-4
Molecular Formula	C₄₀H₃₂N₃P
Molecular Weight	585.68 g/mol
Synonyms	(S)-n-Pinap; (S)-(-)-4-[2-(Diphenylphosphino)-1-naphthyl]-N-[(1S)-1-phenylethyl]phthalazin-1-amine; (S)-N-PINAP; (S)-N-Phenylethyl-PINAP; (S)-1-[(1-Phenylethyl)amino]-4-[2-(diphenylphosphino)-1-naphthalenyl]phthalazine; (S)-N-(1-Phenylethyl)-4-[2-(diphenylphosphino)-1-naphthyl]phthalazin-1-amine; PINAP ligand (S-isomer); Chiral N-PINAP ligand.
EINECS	Contact for details

Quality Control

Our (S)-n-Pinap is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chiral purity, essential for reproducible catalytic performance. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.