Description

n-[(1S)-1-(Hydroxymethyl)-2-Methylpropyl]-5-Methyl-3-Isoxazolecarboxamide is a specialized chiral isoxazole derivative with significant potential in advanced pharmaceutical synthesis. This compound is valued for its role as a key synthetic intermediate or building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily required by research and development teams in the pharmaceutical and biotechnology sectors, particularly those focused on medicinal chemistry, process development, and the synthesis of complex, high-value molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the multi-step synthesis of potential drug candidates, especially those targeting neurological or metabolic pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents with improved efficacy and selectivity.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale, requiring consistent high-purity material.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.
• Bioconjugation & Probe Synthesis: Potential use in creating labeled compounds or molecular probes for biochemical and pharmacological research.

Basic Information

Product Name	n-[(1S)-1-(Hydroxymethyl)-2-Methylpropyl]-5-Methyl-3-Isoxazolecarboxamide
CAS No.	828295-24-5
Molecular Formula	C10H16N2O3
Molecular Weight	212.25 g/mol
Synonyms	(S)-Valinol isoxazole carboxamide; 5-Methyl-3-isoxazolecarboxamide, N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-; (S)-N-(1-Hydroxymethyl-2-methylpropyl)-5-methylisoxazole-3-carboxamide; L-Valinol, 5-methyl-3-isoxazolecarboxamide; Isoxazole-3-carboxamide derivative (S)-isomer; (S)-N-(1-Hydroxy-3-methylbutan-2-yl)-5-methylisoxazole-3-carboxamide; Chiral Isoxazole Amide Intermediate
EINECS	Contact for details

Quality Control

Our n-[(1S)-1-(Hydroxymethyl)-2-Methylpropyl]-5-Methyl-3-Isoxazolecarboxamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Consider storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.